Facial Application of Macrocystis Pyrifera Ferment Shows Promise in Reducing Inflammation and Signs of Aging

12 January 2024

Study Reveals the Potential Benefits of Macrocystis Pyrifera Ferment in Facial Rejuvenation

The pursuit of youthful and healthy-looking skin has long been a priority for many individuals. In recent years, researchers have turned their attention to the potential benefits of natural ingredients in skincare products. A recent study published in the Journal of Cosmetic Dermatology highlights the potential of Macrocystis Pyrifera Ferment, derived from giant sea kelp, in reducing inflammation and signs of aging when applied to the face.

Exploring the anti-inflammatory, anti-aging, and healing properties of Macrocystis Pyrifera Ferment, researchers assembled a dermatology advisory board. The board conducted a comprehensive literature review to assess the evidence supporting the use of this ferment and two creams containing it for facial rejuvenation. The study also aimed to evaluate the role of Macrocystis Pyrifera Ferment in optimizing skin rejuvenation.

Enhancing Barrier Integrity and Promoting Cell Migration

Preclinical research has shown that Macrocystis Pyrifera Ferment enhances the integrity of the skin’s barrier. In vitro studies demonstrated that cells treated with the ferment migrated faster than untreated cells, indicating its potential to support skin healing. Furthermore, topical application of Macrocystis Pyrifera Ferment on human skin explants increased the production of collagen type I, a protein that decreases with age and contributes to visible signs of aging.

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Anti-Inflammatory and Soothing Benefits

Clinical data on Macrocystis Pyrifera Ferment, both alone and in two moisturizing vehicles, revealed anti-inflammatory activity and visible soothing effects. The studies showed a significant decrease in erythema, a common symptom of inflammation, associated with the use of Macrocystis Pyrifera Ferment. These findings suggest that the ferment may help reduce redness and inflammation on the skin.

Improving Barrier Strength and Moisture Levels

Studies investigating the effects of the two creams containing Macrocystis Pyrifera Ferment on the stratum corneum, the outermost layer of the skin, showed promising results. Treatment with these creams enhanced barrier strength and recovery by increasing moisture levels and decreasing transepidermal water loss. These findings indicate that Macrocystis Pyrifera Ferment may help improve the skin’s ability to retain moisture and protect against environmental stressors.

Clinical Effects on Visible Facial Aging

Clinical studies evaluating the effects of creams containing Macrocystis Pyrifera Ferment on visible facial aging reported significant improvements, including a decrease in redness. These findings suggest that the ferment may have anti-aging properties and contribute to a more youthful appearance. Importantly, no confirmed adverse events were observed during the studies, indicating the safety of the ferment-containing creams.


The research on Macrocystis Pyrifera Ferment and its inclusion in skincare products provides valuable insights into the potential benefits of specialized aesthetic skincare. The studies demonstrate the anti-inflammatory, anti-aging, and healing properties of this natural ingredient. While limitations in sample sizes and the absence of biomarkers to validate the ferment’s activity exist, the research highlights the promising role of Macrocystis Pyrifera Ferment in facial rejuvenation. Further studies are warranted to expand our understanding and compare the effects of different facial rejuvenation skincare products. As the pursuit of youthful skin continues, natural ingredients like Macrocystis Pyrifera Ferment offer a potential avenue for achieving healthy and vibrant skin.

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