1,5-anhydro-D-fructose: A Potential Breakthrough in Preventing Aging-Associated Brain Diseases

27 December 2023

New research explores the anti-aging effects of 1,5-anhydro-D-fructose on the brain

As our understanding of the aging process deepens, researchers are constantly seeking innovative ways to combat age-related diseases. In a groundbreaking study published in Aging, scientists from Kagoshima University have discovered that 1,5-anhydro-D-fructose (1,5-AF) may hold the key to preventing aging-associated brain diseases. By activating the 5′-adenosine monophosphate-activated protein kinase (AMPK) pathway, 1,5-AF has shown promising results in animal models of acute ischemic stroke (AIS), stroke-prone spontaneously hypertensive rats (SHRSPs), and the spontaneous senescence-accelerated mouse-prone 8 (SAMP8) model.

Unraveling the Mechanisms of 1,5-AF in Aging-Associated Brain Diseases

1. The Role of AMPK in Aging-Associated Brain Diseases:

AMPK, a metabolic sensor that regulates energy homeostasis and stress resistance, has emerged as a crucial factor in aging-associated brain diseases. Correct regulation of AMPK can enhance overall health and increase longevity. Previous in vitro studies have demonstrated that 1,5-AF has the potential to activate AMPK, prompting researchers to explore its effects in vivo.

2. Promising Results in Animal Models:

To evaluate the effects of 1,5-AF on aging-associated brain diseases, the researchers conducted experiments using animal models of AIS, SHRSPs, and SAMP8 mice. In the AIS model, the administration of 1,5-AF significantly reduced cerebral infarct volume, improved neurological deficits, and decreased mortality rates. In SHRSPs, oral administration of 1,5-AF led to reduced blood pressure and increased survival rates. Furthermore, in the SAMP8 model, 1,5-AF mitigated age-related decline in motor cognitive function.

3. Activation of the PGC-1α/BDNF Pathway:

The researchers discovered that 1,5-AF activated AMPK, which in turn upregulated the peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) and brain-derived neurotrophic factor (BDNF). Aging is known to reduce the expression levels of PGC-1α and BDNF, both of which play crucial roles in maintaining brain health. By activating the AMPK/PGC-1α/BDNF pathway, 1,5-AF demonstrated its potential to counteract the detrimental effects of aging on the brain.

Implications and Future Directions

The findings of this study shed light on the potential of 1,5-AF as a therapeutic agent for aging-associated brain diseases. By activating the AMPK/PGC-1α/BDNF pathway, 1,5-AF shows promise in preventing and mitigating the effects of conditions such as AIS and age-related cognitive decline. However, further research is needed to validate these findings in clinical settings and explore the full extent of 1,5-AF’s therapeutic potential.


The discovery of 1,5-anhydro-D-fructose’s ability to activate the AMPK/PGC-1α/BDNF pathway in animal models of aging-associated brain diseases opens up new possibilities for preventing and treating these conditions. As researchers continue to unravel the intricate mechanisms underlying the aging process, 1,5-AF offers hope for a future where age-related cognitive decline and stroke can be effectively combated. The next step lies in conducting clinical studies to determine the efficacy and safety of 1,5-AF in humans. If successful, this breakthrough could revolutionize the field of neurodegenerative disease research and pave the way for novel therapeutic interventions.

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