1,5-anhydro-D-fructose Shows Promise in Preventing Aging-Associated Brain Diseases, Study Finds

24 December 2023

New research suggests that 1,5-anhydro-D-fructose (1,5-AF) may have anti-aging effects on brain diseases by activating the AMPK/PGC-1α/BDNF pathway.

A groundbreaking study published in the journal Aging has revealed that 1,5-anhydro-D-fructose (1,5-AF) has the potential to combat aging-associated brain diseases. The research, conducted by a team of scientists from Kagoshima University, explored the effects of 1,5-AF on the AMPK/PGC-1α/BDNF pathway in various animal models of age-related brain conditions. The findings suggest that 1,5-AF could activate this pathway, leading to neurovascular protection and potentially preventing the onset of aging-related brain diseases.

The Role of AMPK in Aging-Associated Brain Diseases:

The 5′-adenosine monophosphate-activated protein kinase (AMPK) is a crucial metabolic sensor that regulates energy homeostasis and stress resistance. It plays a vital role in maintaining cellular health and promoting longevity. Scientists have long suspected that AMPK signaling may be involved in the development of aging-associated brain diseases. Previous in vitro studies have demonstrated that 1,5-AF can activate AMPK, making it an intriguing candidate for further investigation.

The Study’s Approach and Findings:

The research team embarked on a series of experiments to evaluate the effects of 1,5-AF on aging-associated brain diseases. They utilized animal models of acute ischemic stroke (AIS), stroke-prone spontaneously hypertensive rats (SHRSPs), and the spontaneous senescence-accelerated mouse-prone 8 (SAMP8) model. In the AIS model, the administration of 1,5-AF via intraperitoneal injection resulted in a reduction in cerebral infarct volume, improved neurological deficits, and decreased mortality rates.

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In the SHRSPs model, oral administration of 1,5-AF led to a decrease in blood pressure and an extension of lifespan. Additionally, in the SAMP8 model, oral administration of 1,5-AF mitigated the age-related decline in motor cognitive function. The researchers observed that the expression levels of peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) and brain-derived neurotrophic factor (BDNF) were reduced with aging. However, 1,5-AF was found to activate AMPK, resulting in the upregulation of the PGC-1α/BDNF pathway.

Implications and Future Directions:

The study’s findings suggest that 1,5-AF has the potential to induce endogenous neurovascular protection, thereby potentially preventing aging-associated brain diseases. However, further clinical studies are needed to validate these results and determine the efficacy of 1,5-AF in the prevention and treatment of such conditions. If successful, this research could pave the way for new therapeutic strategies and interventions targeting aging-related brain diseases.


In an exciting breakthrough, researchers from Kagoshima University have discovered that 1,5-anhydro-D-fructose (1,5-AF) may hold the key to preventing aging-associated brain diseases. By activating the AMPK/PGC-1α/BDNF pathway, 1,5-AF shows promise in promoting neurovascular protection and combating the decline in cognitive function associated with aging. While further studies are needed to confirm these findings, this research opens up new avenues for potential therapeutic interventions in the field of age-related brain diseases.

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