Hyaluronic Acid and Retinol: The Dynamic Duo of Skincare

27 December 2023

Understanding the Roles and Optimal Times for Application

In the quest for flawless skin, two skincare ingredients have risen to the top as true powerhouses: hyaluronic acid and retinol. These “Dream Team” ingredients have gained immense popularity for their remarkable benefits, but knowing how and when to use them is crucial for maximizing their potential. In this article, we explore the roles of hyaluronic acid and retinol, as well as the optimal times for their application, to help you achieve your skincare goals.

Hyaluronic Acid: The Hydration Magic

Hyaluronic acid is a naturally occurring substance in our skin that has gained recognition as the ultimate hydrating hero. Dr Saloni Vora-Gala, a Clinical and Cosmetic Dermatologist, explains that hyaluronic acid has the extraordinary ability to attract and retain moisture, making it essential for maintaining plump, supple, and youthful-looking skin. Regardless of your skin type, whether oily, dry, or sensitive, hyaluronic acid works harmoniously to quench your skin’s thirst for moisture. By creating a moisture-retaining barrier on the skin’s surface, it combats dryness, flakiness, and fine lines.

The Optimal Time: Morning Application

To harness the full potential of hyaluronic acid, incorporating it into your morning skincare routine is recommended. Applying a hyaluronic acid serum in the morning acts as a shield against daily environmental pollutants, helping your skin stay resilient and radiant throughout the day.

Retinol: The Age-Defying Elixir

Retinol, a derivative of vitamin A, is widely regarded as a gold standard in anti-aging skincare. Its ability to accelerate skin cell turnover, stimulate collagen production, and combat fine lines and wrinkles has made it a staple in skincare routines. However, caution is advised due to its potency. Dr Saloni Vora-Gala suggests starting with a lower concentration and gradually increasing usage to avoid potential irritation. Additionally, sun protection becomes even more crucial when using retinol, as it can make the skin more sensitive to sunlight.

The Optimal Time: Evening Application

Due to its potential to increase skin sensitivity and promote cell turnover, retinol is typically recommended for nighttime use. Applying retinol before bed allows your skin to repair and rejuvenate overnight, optimizing its benefits without the interference of sun exposure.

The Collaborative Approach

While hyaluronic acid and retinol excel independently, their potential is magnified when used together. Dr Saloni Vora-Gala suggests applying hyaluronic acid first, immediately after cleansing, while the skin is slightly damp. This allows the acid to trap moisture against the skin’s surface, preparing it for subsequent steps. After hyaluronic acid, incorporate other serums or treatments, and if using retinol, apply it as the last step before moisturizer. This layering technique ensures effective absorption and allows both ingredients to work in harmony to address hydration and anti-aging concerns.

Innovative Approaches: Bioremodeling and Profhilo

In addition to topical application, innovative procedures such as bioremodeling and Profhilo offer a synergistic effect when combined with hyaluronic acid and retinol. Bioremodeling, often associated with the renowned Profhilo procedure, involves injecting ultrapure hyaluronic acid into specific areas of the skin. When combined with topical retinol, these treatments enhance skin hydration, stimulate collagen production, and optimize cellular renewal, resulting in improved texture, elasticity, and a more youthful complexion.


In the world of skincare, hyaluronic acid and retinol have emerged as the dynamic duo. Understanding their roles and the optimal times for their application is essential for unlocking their full potential. By incorporating hyaluronic acid into your morning routine and using retinol in the evening, you can harness the remarkable benefits of both ingredients. Additionally, innovative approaches like bioremodeling and Profhilo offer a synergistic effect when combined with hyaluronic acid and retinol, further enhancing their transformative power. Remember to listen to your skin’s needs and consult with a dermatologist to determine the best products, treatments, and routines for you. With the right approach, you can achieve the skin of your dreams.

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