Hyaluronic Acid and Retinol: The Dynamic Duo of Skincare

26 December 2023

Understanding the roles and optimal application times for hyaluronic acid and retinol

Achieving flawless skin is a dream for many, and the skincare industry offers a multitude of products promising to make that dream a reality. Amidst the vast array of choices, two ingredients have emerged as superstars in the world of skincare: hyaluronic acid and retinol. Often referred to as the “Dream Team” of skincare, these ingredients have gained widespread acclaim for their remarkable benefits. However, understanding their roles and the optimal times for their application is crucial to harnessing their full potential.

Hyaluronic Acid: The Hydration Magic
Hyaluronic acid, a naturally occurring substance within our skin, has gained recognition as the ultimate hydrating hero. Dr. Saloni Vora-Gala, Clinical and Cosmetic Dermatologist and Medical Head at Dr. Sheth’s Skin and Hair Clinics in Mumbai, explains that hyaluronic acid possesses the remarkable ability to attract and retain moisture, making it an essential ingredient for maintaining plump, supple, and youthful-looking skin. Notably, hyaluronic acid is compatible with all skin types, working harmoniously to quench the skin’s thirst for moisture and combat dryness, flakiness, and fine lines.

The Optimal Time: Morning Application
To fully harness the benefits of hyaluronic acid, incorporating it into your morning skincare routine is advised. Applying a hyaluronic acid serum in the morning acts as an effective shield against daily environmental pollutants, helping the skin stay resilient and radiant throughout the day.

Retinol: The Age-Defying Elixir
Retinol, a derivative of vitamin A, has long been revered as a gold standard in anti-aging skincare. Its ability to accelerate skin cell turnover, stimulate collagen production, and combat fine lines and wrinkles has made it a staple in the routines of countless skincare enthusiasts. However, caution is required when using retinol due to its potency. Starting with a lower concentration and gradually increasing usage is recommended to avoid potential irritation. Additionally, sun protection becomes even more critical when using retinol, as it can make the skin more sensitive to sunlight.

The Optimal Time: Evening Application
Due to its potential to increase skin sensitivity and promote cell turnover, retinol is typically recommended for nighttime use. Applying retinol before bed allows the skin to repair and rejuvenate overnight, maximizing the ingredient’s benefits without the interference of sun exposure.

The Collaborative Approach
While hyaluronic acid and retinol work wonders independently, their potential is magnified when used together. Dr. Saloni Vora-Gala advises applying hyaluronic acid first, immediately after cleansing, while the skin is still slightly damp. This allows the acid to trap moisture against the skin’s surface, preparing it for subsequent steps. After hyaluronic acid, other serums or treatments can be incorporated, and if using retinol, it should be applied as the last step before moisturizer. This layering technique ensures that both ingredients are absorbed effectively and work in harmony to address hydration and anti-aging concerns.

The Power of Bioremodeling
For hyaluronic acid, bioremodeling, synonymous with the renowned Profhilo procedure, offers effective and long-lasting results. Profhilo involves injecting ultrapure hyaluronic acid into specific areas of the skin. When combined with the concurrent application of topical retinol, the results can be even more remarkable. Profhilo enhances skin hydration and stimulates collagen production, leading to improved texture and elasticity. Retinol accelerates cellular renewal, optimizing the skin’s capacity to absorb and retain the benefits of Profhilo. Together, these treatments promote a more vibrant and youthful complexion, effectively addressing both hydration and rejuvenation aspects.


Hyaluronic acid and retinol have rightfully earned their reputation as the “Dream Team” of skincare. Understanding their roles and the optimal times for their application is crucial for reaping their full benefits. By incorporating hyaluronic acid into your morning routine and using retinol in the evening, you can maximize their individual effects. Additionally, when used together strategically, these ingredients can create a powerful synergy, resulting in hydrated, rejuvenated, and youthful-looking skin. Remember to listen to your skin’s needs and consult with a dermatologist to determine the best products, treatments, and routines for your specific needs.

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