New Drug Offers Potential to Extend Lifespan of Dogs: What You Need to Know

27 December 2023

LOY-001, an innovative medication, aims to slow down the aging process in large adult dogs.

In a groundbreaking development, a San Francisco-based company called Loyal has developed a drug, LOY-001, that has the potential to extend the lifespan of dogs. This medication, currently in the research phase, specifically targets large adult dogs, who generally have shorter lifespans compared to their smaller counterparts. By interacting with a hormone known as insulin growth factor-1 (IGF-1), LOY-001 aims to slow down the aging process in dogs and improve their overall quality of life. Let’s delve deeper into the key aspects of this exciting new drug.

How Does LOY-001 Work?

LOY-001 works by interacting with IGF-1, a hormone that plays a role in both growth and aging in dogs. Research has shown that dogs with lower insulin levels tend to have reduced frailty and a higher quality of life. Large dogs naturally have higher levels of IGF-1, which is believed to contribute to their shorter lifespans. By targeting IGF-1, LOY-001 aims to regulate the hormone and potentially slow down the aging process in large adult dogs.

Who Is LOY-001 Designed For?

LOY-001 is specifically designed for large adult dogs, who are more prone to age-related health issues and have shorter lifespans compared to smaller dogs. By focusing on this demographic, the medication aims to address the specific needs of these dogs and potentially extend their lifespan.

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Administration and Side Effects

LOY-001 is an injectable medication that would be administered by a veterinarian every three to six months. This long-acting formula ensures that dogs receive the necessary dosage consistently over an extended period. Studies conducted so far have shown that the most common side effects of LOY-001 are mild and temporary gastrointestinal distress in dogs.

The Road to FDA Approval

While LOY-001 shows promising potential, it is not yet available to pet owners. The drug is currently undergoing rigorous testing and research to gain approval from the U.S. Food and Drug Administration (FDA). Loyal announced that the FDA has provided positive feedback based on the data collected so far. However, full FDA approval requires the completion of a large-scale clinical trial, as well as the review of safety and manufacturing data. Loyal aims to obtain conditional FDA approval for LOY-001 by 2026.


The development of LOY-001 offers a glimmer of hope for dog owners who wish to extend the lifespan and improve the quality of life for their beloved pets. By targeting the hormone IGF-1, this innovative medication has the potential to slow down the aging process in large adult dogs, who often face age-related health issues. While more research and FDA approval are still needed, the potential benefits of LOY-001 are promising. As we await further developments, dog owners can look forward to a future where the term “dog years” may take on a whole new meaning.

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