Groundbreaking Drug Aims to Extend the Lifespan of Dogs: Introducing LOY-001

22 December 2023

LOY-001, a new medication developed by San Francisco-based company Loyal, shows promise in extending the lifespan of large adult dogs.

In a groundbreaking development, a new drug called LOY-001 is set to revolutionize the way we think about a dog’s lifespan. Developed by Loyal, a San Francisco-based company, LOY-001 aims to extend the lives of large adult dogs, who typically have shorter lifespans compared to their smaller counterparts. By targeting a hormone that is believed to accelerate aging in dogs, LOY-001 presents a promising solution for pet owners seeking to enhance their furry companions’ longevity. Although the drug is not yet available to the public, Loyal aims to bring it to market by 2026, pending approval from the U.S. Food and Drug Administration (FDA).

Unveiling the Mechanism Behind LOY-001

LOY-001 functions by interacting with insulin growth factor-1 (IGF-1), a hormone that plays a dual role in promoting growth and aging in dogs. Research has indicated that dogs with lower insulin levels tend to exhibit reduced frailty and enjoy a higher quality of life compared to those with higher insulin levels. Large dogs naturally have higher levels of IGF-1, which contributes to their shorter lifespans. LOY-001 aims to modulate IGF-1 levels, thereby slowing down the aging process and potentially extending the lifespan of large adult dogs.

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Administration and Potential Side Effects

LOY-001 is administered as a long-acting injectable medication, ensuring convenience for both veterinarians and pet owners. The drug’s effects last for three to six months, reducing the frequency of administration. However, like any medication, LOY-001 does come with potential side effects. Studies conducted so far have shown that dogs may experience mild and temporary gastrointestinal distress. While these side effects are generally well-tolerated, further research is needed to fully understand the long-term effects and safety profile of LOY-001.

The Road to FDA Approval

Despite the promising potential of LOY-001, it is important to note that the drug is not yet available to the public. Loyal announced that the FDA has shown interest in the preliminary data, indicating the drug’s potential effectiveness. However, full FDA approval requires the completion of a large-scale clinical trial, as well as a thorough review of safety and manufacturing data. Loyal aims to obtain conditional FDA approval for LOY-001 by 2026, paving the way for a groundbreaking solution to extend the lifespan of large adult dogs.


LOY-001 presents an exciting prospect for pet owners looking to give their beloved dogs a longer and healthier life. By targeting the hormone IGF-1, which is known to accelerate aging in dogs, LOY-001 offers a potential solution to extend the lifespan of large adult dogs. With its long-acting injectable formulation, LOY-001 aims to provide convenience and ease of administration. However, further research and FDA approval are necessary before LOY-001 can be made available to the public. As the world eagerly awaits the outcome of clinical trials, LOY-001 represents a significant step forward in the quest to enhance the lives of our furry companions.

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